Article

Structural modeling and experimental validation define the MxA-Thogotovirus nucleoprotein interface that drives restriction and escape

2026-08-09

Abstract excerpt

The human MxA (myxovirus resistance protein A) host restriction factor inhibits orthomyxoviruses, such as Thogotovirus (THOV) and influenza A virus (IAV), by binding to their nucleoproteins. Despite being discovered over six decades ago, how MxA interacts with viral targets remains unclear. Earlier studies using evolutionary analysis and mutagenesis showed that the MxA L4 loop, especially a hydrophobic aromatic am...

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Literature Corpus work: 4b746a0f-0e3f-580e-a878-08ed43d34a12
DOI: 10.64898/2026.08.07.743570

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