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Article

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA.

PLoS pathogens - 1 Mar 2017

Ashenberg Orr, Padmakumar Jai, Doud Michael B, Bloom Jesse D

Abstract excerpt

The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP). Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and avian viral strains to identify amino-acid differences in NP that affect sensitivity to MxA. However, this strategy is limited to identifying sites in NP where...

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Identifiers

PMID: 28346537
DOI: 10.1371/journal.ppat.1006288
PMCID: PMC5383324

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