Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.

doi:10.1074/jbc.M113.543892

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Article

Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.

The Journal of biological chemistry - 28 Feb 2014

Patzina Corinna, Haller Otto, Kochs Georg

Abstract excerpt

The interferon-induced dynamin-like MxA protein has broad antiviral activity against many viruses, including orthomyxoviruses such as influenza A and Thogoto virus and bunyaviruses such as La Crosse virus. MxA consists of an N-terminal globular GTPase domain, a connecting bundle signaling element, and the C-terminal stalk that mediates oligomerization and antiviral specificity. We previously reported that the...

Topics

Amino Acid Motifs
Animals
Chlorocebus aethiops
Humans
Influenza A Virus, H5N1 Subtype
Influenza, Human
Mutation
Myxovirus Resistance Proteins
Protein Structure, Tertiary
Structure-Activity Relationship
Thogotovirus

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Identifiers

PMID: 24448803
DOI: 10.1074/jbc.M113.543892
PMCID: PMC3937669

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