Article

An all-atom view into the disordered interaction interface of the TRIM5 <i>α</i> PRYSPRY domain and the HIV capsid

2024-12-09

Abstract excerpt

Tripartite motif-containing protein 5, alpha isoform (TRIM5 α ) is an innate immune factor that provides rhesus macaques with immunity to HIV. Despite high sequence similarity to rhesus TRIM5 α , human TRIM5 α weakly restricts HIV without the introduction of mutations. The structural underpinnings of this functional difference are poorly understood because the interaction interface between TRIM5 α and its targ...

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Literature Corpus work: 48d85b4e-eb13-5c12-ab2a-e8aa3e2929d7
DOI: 10.1101/2024.12.06.627233

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