Article

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction

2024-10-10

Abstract excerpt

Antiviral restriction factors such as MxA (myxovirus resistance protein A) inhibit a broad range of viruses. However, they face the challenge of maintaining this breadth as viruses evolve to escape their defense. Viral escape drives restriction factors to evolve rapidly, selecting for amino acid changes at their virus-binding interfaces to regain defense. How do restriction factors balance the breadth of antiviral...

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Literature Corpus work: b5d931e8-b2da-53d7-b8c8-f37be89a48e6
DOI: 10.1101/2024.10.10.617484

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