Article

MxB restricts HIV-1 by targeting the tri-hexamer interface of the viral capsid

2018-10-15

Abstract excerpt

Myxovirus resistance protein B (MxB) is an interferon-inducible restriction factor of HIV-1 that blocks nuclear import of the viral genome. Evidence suggests that MxB recognizes higher-order interfaces of the HIV capsid lattice, but the mechanistic details of this interaction are not known. Previous studies have mapped the restriction activity of MxB to its N-terminus encompassing a triple arginine motif 11 RRR...

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Literature Corpus work: ee0059de-c84e-515d-9d54-056345b8a4ef
DOI: 10.1101/444067

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