Back to search

Article

The Immune-Evasive Proline 283 Substitution in Influenza Nucleoprotein Increases Aggregation Propensity Without Altering the Native Structure

2023-09-12

Abstract excerpt

Nucleoprotein (NP) is a key structural protein of influenza ribonucleoprotein complexes and is central to viral RNA packing and trafficking. In human cells, the interferon induced Myxovirus resistance protein 1 (MxA) binds to NP and restricts influenza replication. This selection pressure has caused NP to evolve a few critical MxA-resistant mutations, particularly the highly conserved Pro283 substitution. Previous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9efbca85-815e-5fde-ba57-1a76ee282311
DOI
10.1101/2023.09.08.556894
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Immune-Evasive Proline 283 Substitution in Influenza Nucleoprotein Increases Aggregation Propensity Without Altering the Native StructureDOI 10.1101/2023.09.08.556894
Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperonesSemantic proximity
NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A VirusesSemantic proximity
Structural modeling and experimental validation define the MxA-Thogotovirus nucleoprotein interface that drives restriction and escapeSemantic proximity
The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxASemantic proximity
Deep Mutational Scanning Identifies Sites in Influenza Nucleoprotein That Affect Viral Inhibition by MxASemantic proximity
Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibilitySemantic proximity
Functional and antigenic constraints on the Nipah virus fusion proteinSemantic proximity
NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.Semantic proximity
Molecular determinants of fibrillation in a viral amyloidogenic domain from combined biochemical and biophysical studiesSemantic proximity
Enhancing the protein fitness of interferon-lambda through computational design and glyco-engineering for prophylactic nasal drugs against respiratory virusesSemantic proximity
Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA.Semantic proximity
Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptationSemantic proximity
Select a neighboring publication to make it the new centre.