Article

Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Chikungunya virus (CHIKV) infects both humans and mosquitoes during its transmission cycle. How the virus’s envelope proteins mediate entry in cells from such different species is unclear. MXRA8 is a receptor for CHIKV in mammalian cells, but the receptor(s) in mosquito cells remains unknown. Here we use pseudovirus deep mutational scanning to measure how nearly all amino-acid mutations to the C...

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Literature Corpus work: a80615e6-a8d1-5e0f-b4a2-81b052899844
DOI: 10.1101/2025.08.25.672233

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