Article

The N-terminal domain of MX1 proteins is essential for their antiviral activity against different families of RNA viruses

2022-05-10

Abstract excerpt

Myxovirus resistance protein 1 (MX1) and MX2, are homologous, dynamin-like large GTPases, induced upon interferon (IFN) exposure. Human MX1 (HsMX1) is known to inhibit many viruses, including influenza A virus (IAV), by likely acting at various steps of their life cycles. Despite decades of studies, the mechanism(s) of action with which MX1 proteins manage to inhibit target viruses is not fully understood. MX1 pro...

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Literature Corpus work: c85ef7d4-adb0-5216-b940-e55135bafaeb
DOI: 10.1101/2022.05.10.491305

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