Article

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

2024-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary defects in the function of the Kir7.1 in the retinal pigment epithelium are associated with the ocular diseases retinitis pigmentosa, Leber congenital amaurosis, and snowflake vitreal degeneration. Studies also suggest that Kir7.1 may be regulated by a GPCR, the melanocortin-4 receptor, in certain hypothalamic neurons. We present the first structures of human Kir7.1 and describe the c...

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Literature Corpus work: fe40fc0d-fcf2-59c4-b2c6-f32a95818f98
DOI: 10.1101/2024.06.07.597981

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