Article
A drug pocket at the lipid bilayer-potassium channel interface.
Science advances - 1 Oct 2017
Ottosson Nina E, Silverå Ejneby Malin, Wu Xiongyu, Yazdi Samira, Konradsson Peter, Lindahl Erik, Elinder Fredrik
Abstract excerpt
Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and...
Topics
- Binding Sites
- Kinetics
- Ligands
- Lipid Bilayers
- Molecular Conformation
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Molecular Structure
- Mutation
- Potassium Channels
- Protein Binding
- Protein Multimerization
- Quantitative Structure-Activity Relationship
- Static Electricity