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Article

A drug pocket at the lipid bilayer-potassium channel interface.

Science advances - 1 Oct 2017

Ottosson Nina E, Silverå Ejneby Malin, Wu Xiongyu, Yazdi Samira, Konradsson Peter, Lindahl Erik, Elinder Fredrik

Abstract excerpt

Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and...

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Identifiers

PMID: 29075666
DOI: 10.1126/sciadv.1701099
PMCID: PMC5656419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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