Article

Excessive Ca <sup>2+</sup> -dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

2026-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic-associated steatohepatitis (MASH) involves hepatocyte damage that cannot be explained solely by lipid accumulation. Here, to discover injury-specific pathways, we focused on a gene of uncertain function, EF-Hand Domain Family Member D1 (EFHD1), identified in human genome-wide association studies of liver injury but not liver fat. We show that EFHD1, a Ca 2+ -dependent actin crosslink...

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Literature Corpus work: 4b3c11c7-9a41-55dc-b83a-0728c0af10fa
DOI: 10.64898/2026.02.13.705622

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