Article

ERAD deficiency disrupts mitochondrial bioenergetics by altering MAM Ca2+ in human hepatic cells

2024-09-23

Abstract excerpt

<title>Abstract</title> <p>Mitochondria and the endoplasmic reticulum (ER) physically and functionally interact, regulating each other’s function, but the molecular mechanisms remain not fully understood. In this study, we revealed that ER-associated degradation (ERAD), an ER protein quality control mechanism, governs ER Ca2+ entry into mitochondria by mitochondria-associated ER membrane (MAM) in hepatic cells. I...

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Literature Corpus work: e78da7cc-6268-5b62-b9aa-c0b9a00f8a7d
DOI: 10.21203/rs.3.rs-4939621/v1

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