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Article

KEAP1 retention in phase-separated p62 bodies drives liver damage in autophagy-deficient conditions

2025-02-21

Abstract excerpt

Phase-separated p62 bodies activate NRF2, a key transcription factor for antioxidant response, by sequestering KEAP1, which targets NRF2 for degradation. Although p62 bodies containing KEAP1 are degraded by autophagy, they accumulate in various liver disorders. Their precise disease role remains unclear. We show that excessive KEAP1 retention in p62 bodies and NRF2 activation are major causes of liver damage when...

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Identifiers and source

Literature Corpus work
242cbe8a-04b1-5bab-917b-d08f64e4d541
DOI
10.1101/2025.02.21.639409
Open publication

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KEAP1 retention in phase-separated p62 bodies drives liver damage in autophagy-deficient conditionsDOI 10.1101/2025.02.21.639409
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