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Article

Contribution of P2X1 receptor intracellular basic residues to channel properties.

Biochemical and biophysical research communications - 10 Nov 2006

Vial Catherine, Rigby Richard, Evans Richard J

Abstract excerpt

The intracellular amino and carboxy termini of P2X receptors have been shown to contribute to the regulation of ATP evoked currents. In this study we produced, and expressed in Xenopus oocytes, individual alanine point mutants of positively charged amino acids (eight lysine, seven arginine and one histidine) in the intracellular domains of the human P2X1 receptor. The majority of these mutations had no effect on...

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PMID: 16997281
DOI: 10.1016/j.bbrc.2006.09.038

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