Article
Molecular physiology of SLC4 anion exchangers.
Experimental physiology - 1 Jan 2006
Alper Seth L
Abstract excerpt
Plasmalemmal Cl- -HCO3- exchangers regulate intracellular pH and [Cl-] and cell volume. In polarized epithelial cells, they contribute also to transepithelial secretion and reabsorption of acid-base equivalents and of Cl-. Members of both the SLC4 and SLC26 mammalian gene families encode Na+-independent Cl- -HCO3- exchangers. Human SLC4A1/AE1 mutations cause either the erythroid disorders spherocytic haemolytic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
