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Article

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains.

Pflugers Archiv : European journal of physiology - 1 Nov 2007

Yuill K H, Stansfeld P J, Ashmole I, Sutcliffe M J, Stanfield P R

Abstract excerpt

We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1. We used site directed mutagenesis and electrophysiological studies, assisted by structural models built through computational methods. We have measured selectivity in channels expressed in Xenopus oocytes, using voltage clamp to...

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Identifiers

PMID: 17541788
DOI: 10.1007/s00424-007-0282-7
PMCID: PMC2492388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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