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Article

Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.

The Journal of general physiology - 3 Feb 2020

Lynagh Timothy, Flood Emelie, Boiteux Céline, Sheikh Zeshan Pervez, Allen Toby W, Pless Stephan A

Abstract excerpt

Trimeric acid-sensing ion channels (ASICs) contribute to neuronal signaling by converting extracellular acidification into excitatory sodium currents. Previous work with homomeric ASIC1a implicates conserved leucine (L7') and consecutive glycine-alanine-serine (GAS belt) residues near the middle, and conserved negatively charged (E18') residues at the bottom of the pore in ion permeation and/or selectivity....

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Identifiers

PMID: 31952079
DOI: 10.1085/jgp.201812297
PMCID: PMC7062507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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