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Article

Ion Selectivity in P2X Receptors: A Comparison between hP2X3 and zfP2X4.

The journal of physical chemistry. B - 16 Dec 2021

Racigh Vanesa, Pierdominici-Sottile Gustavo, Palma Juliana

Abstract excerpt

Charge discrimination in P2X receptors occurs in two stages. The first stage takes place in the extracellular vestibule. The second one happens as the ions travel across the pore. The search of the amino acids required to achieve these goals has focused on negatively charged residues conserved among the family members. This strategy, however, has afforded baffling results since residues that strongly influence...

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Identifiers

PMID: 34851131
DOI: 10.1021/acs.jpcb.1c07308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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