Article

HIV coinfection is associated with low fitness <i>rpoB</i> variants in rifampicin-resistant <i>Mycobacterium tuberculosis</i>

2020-07-22

Abstract excerpt

We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, sugg...

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Literature Corpus work: 4a7be088-a941-5bb6-84c3-c0d06407f43a
DOI: 10.1101/2020.07.20.208835

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