Compensatory mutations are associated with increased <i>in vitro</i> growth in resistant clinical samples of <i>Mycobacterium tuberculosis</i>

Abstract excerpt

Mutations in Mycobacterium tuberculosis associated with resistance to antibiotics often come with a fitness cost for the bacteria. Resistance to the first-line drug rifampicin leads to lower competitive fitness of M. tuberculosis populations when compared to susceptible populations. This fitness cost, introduced by resistance mutations in the RNA polymerase, can be alleviated by compensatory mutations (CMs) in o...

Topics

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• DNA-Directed RNA Polymerases
• Evolution and Genetic Dynamics
• Mutation
• Mycobacterium research and diagnosis
• Mycobacterium tuberculosis
• Rifampin
• Tuberculosis
• Tuberculosis Research and Epidemiology

Identifiers and source

Literature Corpus work

0d5b243c-f58c-568c-a83f-f27474450762

DOI

10.1101/2023.06.21.545231