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Novel and Reported Compensatory Mutations in <i>rpoABC</i> Associate Specifically with Predominant <i>Mycobacterium tuberculosis</i> Rifampicin Resistance Marker <i>rpoB</i> :S450L

2022-02-24

Abstract excerpt

<h4>Background</h4> Rifampicin (RIF) is a key first-line drug used to treat tuberculosis, a pulmonary disease caused by Mycobacterium tuberculosis . However antibiotic resistance to RIF is prevalent despite an apparent fitness cost. RIF resistance is primarily caused by mutations in the RIF resistance determining region in the rpoB gene, at the cost of slower growth in rich media. Compensatory mutations in the...

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Literature Corpus work
3327eb6a-ffd8-5844-856d-ee77900139a1
DOI
10.1101/2022.02.22.481565
Open publication

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Novel and Reported Compensatory Mutations in <i>rpoABC</i> Associate Specifically with Predominant <i>Mycobacterium tuberculosis</i> Rifampicin Resistance Marker <i>rpoB</i> :S450LDOI 10.1101/2022.02.22.481565
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