Article

Borderline <i>rpoB</i> mutations transmit at the same rate as common <i>rpoB</i> mutations in a tuberculosis cohort in Bangladesh

2023-02-15

Abstract excerpt

The spread of multidrug-resistant tuberculosis (MDR-TB) is a growing problem in many countries worldwide. Resistance to one of the primary first-line drugs, rifampicin, is caused by mutations in the Mycobacterium tuberculosis rpoB gene. While some of these infrequent mutations show lower fitness in vitro than more common mutations, their in vivo fitness is currently unknown. We used a dataset of 394 whole geno...

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Literature Corpus work: 9fe32938-ca85-5c8e-9bfc-4a3764fe94af
DOI: 10.1101/2023.02.14.528501

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