Article

Patterns of compensatory mutations in <i>rpoA/B/C</i> genes of multidrug resistant <i>M. tuberculosis</i> in Uganda

2025-07-11

Abstract excerpt

Mutations in rpoB , a gene that encodes the bacterial RNA polymerase (RNAP) beta-subunit, can cause high-level resistance to rifampicin. Approximately 95% of rifampicin-resistant Mycobacterium tuberculosis clinical isolates possess mutations in an 81-base pair rpoB region referred to as the rifampicin-resistance determining region ( rpoB /RRDR). Also, rifampicin-resistant M. tuberculosis clinical isolates car...

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Literature Corpus work: 40844c53-2eda-5aa6-a807-a4100574422c
DOI: 10.1101/2025.07.11.664293

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