Article
Characterization of Mutations Conferring Resistance to Rifampin in Mycobacterium tuberculosis Clinical Strains.
Antimicrobial agents and chemotherapy - 1 Oct 2018
Jagielski Tomasz, Bakuła Zofia, Brzostek Anna, Minias Alina, Stachowiak Radosław, Kalita Joanna, Napiórkowska Agnieszka, Augustynowicz-Kopeć Ewa, Żaczek Anna, Vasiliauskiene Edita, Bielecki Jacek, Dziadek Jarosław
Abstract excerpt
Resistance of Mycobacterium tuberculosis to rifampin (RMP), mediated by mutations in the rpoB gene coding for the beta-subunit of RNA polymerase, poses a serious threat to the efficacy of clinical management and, thus, control programs for tuberculosis (TB). The contribution of many individual rpoB mutations to the development and level of RMP resistance remains elusive. In this study, the incidence of mutations...
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