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The impact of drug resistance on <i>Mycobacterium tuberculosis</i> physiology: what can we learn from rifampicin?

1 Jan 2014

Abstract excerpt

The emergence of drug-resistant pathogens poses a major threat to public health. Although influenced by multiple factors, high-level resistance is often associated with mutations in target-encoding or related genes. The fitness cost of these mutations is, in turn, a key determinant of the spread of drug-resistant strains. Rifampicin (RIF) is a frontline anti-tuberculosis agent that targets the rpoB-encoded β...

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PMID: 26038512
DOI: 10.1038/emi.2014.17

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