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Rifampicin and rifabutin resistance in 1000 <i>Mycobacterium tuberculosis</i> clinical isolates

2018-09-25

Abstract excerpt

<h4>Synopsis</h4> Drug resistant tuberculosis (TB) remains a public health challenge with limited treatment options and high associated mortality. Rifamycins are among the most potent anti-TB drugs, and the loss of susceptibility to these agents, a hallmark of MDR TB, is considered a substantial therapeutic challenge. Rifamycins are known to target the RpoB subunit of RNA polymerase; however, our understanding of...

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Literature Corpus work
0a886ff6-a635-5527-823b-ff9be7d979b1
DOI
10.1101/425652
Open publication

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