HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.

doi:10.1128/AAC.00782-20

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HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 21 Sept 2020

Loiseau Chloé, Brites Daniela, Reinhard Miriam, Zürcher Kathrin, Borrell Sonia, Ballif Marie, Fenner Lukas, Cox Helen, Rutaihwa Liliana K, Wilkinson Robert J, Yotebieng Marcel, Carter E Jane, Abimiku Alash'le, Marcy Olivier, Gotuzzo Eduardo, Avihingsanon Anchalee, Zetola Nicola, Doulla Basra, Böttger Erik C, Egger Matthias, Gagneux Sebastien

Abstract excerpt

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of...

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PMID: 32718966
DOI: 10.1128/AAC.00782-20
PMCID: PMC7508592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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