Article

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood biomarkers in Huntington’s disease

2025-12-16

Abstract excerpt

Transcriptional dysregulation is among the most prominent molecular alterations in Huntington’s disease (HD). It is not confined to brain but is also extended to peripheral tissues and cells, enabling minimally invasive screens aimed at identifying transcriptional surrogates of the health status in HD mutation carriers. Nonetheless, transcriptomics approaches have failed to identify consistent candidates from peri...

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Literature Corpus work: 4a62be64-313e-58df-9b92-a63ded393673
DOI: 10.64898/2025.12.14.694089

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