Article

A meta-analysis of transcriptomic profiles from Huntington’s disease patients points to a pathophysiological role of CDC42, NFY, DLX1 and PRMT3

2021-01-07

Abstract excerpt

Description of robust transcriptomic alterations in Huntington’s disease is essential to identify targets for biochemical studies and drug development. We analysed publicly available transcriptome data from the brain and blood of 220 HD patients and 241 healthy controls and identified 737 and 661 genes with robustly altered mRNA levels in the brain and blood of HD patients, respectively. In the brain, a subnetwork...

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Literature Corpus work: b690e2fd-9fc5-545e-97d5-54f9d73f5383
DOI: 10.1101/2021.01.04.425185

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