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Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

21 Mar 2017

Abstract excerpt

There is widespread transcriptional dysregulation in Huntington's disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem changes. However, mutant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available and contains cells that are dysfunctional in HD, could act as a surrogate for brain tissue. We conducted an RNA-Seq transcriptomic analysis...

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PMID: 28322270
DOI: 10.1038/srep44849

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