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Article

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.

Genome biology - 4 Mar 2021

Sorek Matan, Oweis Walaa, Nissim-Rafinia Malka, Maman Moria, Simon Shahar, Hession Cynthia C, Adiconis Xian, Simmons Sean K, Sanjana Neville E, Shi Xi, Lu Congyi, Pan Jen Q, Xu Xiaohong, Pouladi Mahmoud A, Ellerby Lisa M, Zhang Feng, Levin Joshua Z, Meshorer Eran

Abstract excerpt

BACKGROUND: Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset phenomenon remains largely unexplained. RESULTS: Analyzing single-cell RNA sequencing from Alzheimer's disease (AD) and Huntington's disease (HD) patients, we find increased transcriptional heterogeneity in...

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Identifiers

PMID: 33663567
DOI: 10.1186/s13059-021-02301-6
PMCID: PMC7934477

Genes

CHD8

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