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Article

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood in Huntington's disease.

Scientific reports - 26 May 2026

Martín-Climent Paula, Ortuño-Miquel Samanta, Gallego-Serna Juan F, Martí-Martínez Silvia, Valor Luis M

Abstract excerpt

Transcriptional dysregulation is among the most prominent molecular alterations in Huntington's disease (HD). It is not confined to the brain but also extends to peripheral tissues and cells, enabling minimally invasive screening strategies to identify transcriptional surrogates of the health status in HD mutation carriers. Nonetheless, transcriptomics approaches have failed to identify consistent candidates from...

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Identifiers

PMID: 42192121
DOI: 10.1038/s41598-026-54412-4
PMCID: PMC13434588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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