Article

Repurpose of Ritlecitinib Reduces Neointima Formation and Enhances Endothelial Recovery Following Vascular Injury

2025-09-25

Abstract excerpt

<h4>Background</h4> Neointimal hyperplasia after vascular injury reflects excess smooth muscle cell (SMC) proliferation with impaired endothelial recovery. We tested the hypothesis that selective Janus kinase 3 (JAK3) inhibition with the FDA-approved drug Ritlecitinib limits neointima while accelerating reendothelialization. <h4>Methods</h4> We used mouse carotid wire injury and a human internal mammary artery (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a45f1b4-eeb1-531a-9d6c-96d1e6e2a87e
DOI: 10.1101/2025.09.23.678172

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurpose of Ritlecitinib Reduces Neointima Formation and Enhances Endothelial Recovery Following Vascular InjuryDOI 10.1101/2025.09.23.678172Read

Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validationSemantic proximity Read

Nitazoxanide activates BMP9-ALK1-SMAD signaling cascade and improves HHT vascular pathologySemantic proximity Read

Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO₂.Semantic proximity Read

Targeting PDK4 attenuates neointimal hyperplasia and regulates VSMC phenotypic switching, apoptosis, and autophagy.Semantic proximity Read

Human Saphenous Vein Ex Vivo Culture as a Translational Model of Intimal HyperplasiaSemantic proximity Read

ALK5/Smad signaling mediates rapamycin therapeutic response and TET2-dependent chromatin remodeling in vascular smooth muscle cell differentiationSemantic proximity Read

Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells.Semantic proximity Read

METTL3 Aggravates Intimal Hyperplasia by Facilitating the m <sup>6</sup> A-YTHDC1-dependent SGK1 Gene TranscriptionSemantic proximity Read

Xenium In Situ Profiling Uncovers HSPG-Dependent SULF1/VEGFR2 Signaling Mediating Vascular Remodeling in Moyamoya DiseaseSemantic proximity Read

Cardiovascular risk gene <i>HDAC9</i> drives maladaptive vascular remodeling after arterial injurySemantic proximity Read

Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.Semantic proximity Read

Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.Semantic proximity Read