Article
Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells.
Scientific reports - 10 Feb 2023
Kim Yerin, Yu Namhee, Jang Ye Eun, Lee Eunkyung, Jung Yeonjoo, Lee Doo Jae, Taylor W Robert, Jo Hanjoong, Kim Jaesang, Lee Sanghyuk, Kang Sang Won
Abstract excerpt
Endothelial dysfunction and inflammatory immune response trigger dedifferentiation of vascular smooth muscle cells (SMCs) from contractile to synthetic phenotype and initiate arterial occlusion. However, the complex vascular remodeling process playing roles in arterial occlusion initiation is largely unknown. We performed bulk sequencing of small and messenger RNAs in a rodent arterial injury model. Bioinformatic...
Topics
- Animals
- Humans
- Rats
- Bone Morphogenetic Protein 7
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- MicroRNAs
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle