Article

Human Saphenous Vein Ex Vivo Culture as a Translational Model of Intimal Hyperplasia

2025-06-23

Abstract excerpt

<h4>BACKGROUND</h4> Intimal hyperplasia (IH) significantly limits the long-term patency of saphenous vein grafts following bypass surgery, with no human models available to fully understand its complex pathogenesis. Although animal models, primarily murine systems, have provided mechanistic insights into IH, limitations persist in translating these findings to human pathophysiology. Here, we evaluate the translat...

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Literature Corpus work: 87e3a290-dac7-5fc8-9cab-4578cc1f0d7f
DOI: 10.1101/2025.06.17.660253

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