Article

Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation

2023-10-09

Abstract excerpt

<h4>Background: </h4> Coronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal hyperplasia (NIH) of graft and anastomotic sites. Although sirolimus and rosuvastatin individually inhibit NIH progression, the efficacy of combination treatment remains unknown. Methods We identified cross-targets associated with CABG, sirolimus, and ro...

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Literature Corpus work: b0da3ef0-077d-5da9-bd5e-f012583cc292
DOI: 10.21203/rs.3.rs-3344075/v1

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