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Article

C-Kit Is Essential for Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and In Vivo After Injury.

Cells - 21 Oct 2025

Siracusa Chiara, Canino Giovanni, Scalise Mariangela, Marino Fabiola, Pagano Loredana, Santamaria Gianluca, Torella Annalaura, De Rosa Salvatore, Torella Daniele, Cianflone Eleonora

Abstract excerpt

Pathological vascular remodeling-central to restenosis, atherosclerosis, and vasculo-proliferative diseases-depends on the phenotypic switching of vascular smooth muscle cells (VSMCs) from a quiescent, contractile state to a synthetic, proliferative program. Although the receptor tyrosine kinase c-Kit is implicated in proliferation, migration, and tissue repair, its role in VSMC plasticity has yet to be fully...

Read the complete abstract on PubMed

Topics

Animals
Proto-Oncogene Proteins c-kit
Muscle, Smooth, Vascular
Mice
Phenotype
Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Proliferation

Cellular Senescence

Male

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 41148855
DOI: 10.3390/cells14201641
PMCID: PMC12564463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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