Article

Xenium In Situ Profiling Uncovers HSPG-Dependent SULF1/VEGFR2 Signaling Mediating Vascular Remodeling in Moyamoya Disease

2026-05-01

Abstract excerpt

<h4>Background</h4> Moyamoya disease (MMD) is characterized by progressive arterial stenosis and abnormal collateral formation, but the spatial organization of vessel-wall abnormalities remains incompletely understood. <h4>Methods</h4> We combined Xenium in situ spatial transcriptomics and multiplex immunofluorescence in superficial temporal artery samples from patients with MMD and controls, and performed gain-...

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Literature Corpus work: 4bea47a2-057f-50fd-8793-bfa1ed0e1d99
DOI: 10.64898/2026.04.28.721514

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