Article

Nitazoxanide activates BMP9-ALK1-SMAD signaling cascade and improves HHT vascular pathology

2026-05-14

Abstract excerpt

<h4>Objective</h4> Hereditary hemorrhagic telangiectasia (HHT) is a vascular genetic disorder caused by endothelial cell dysfunction and characterized by telangiectasias and arteriovenous malformations (AVMs). HHT results primarily from loss-of-function mutations affecting components of the BMP9-ALK1-ENG-SMAD signaling cascade, a pathway essential for endothelial quiescence and vascular homeostasis, and currently...

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Literature Corpus work: 5a7dbac2-eb80-5ae0-9fda-878a716e8b03
DOI: 10.64898/2026.05.12.724733

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