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Article

Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.

Journal of the American Heart Association - 27 Jan 2014

Yoshida Tadashi, Yamashita Maho, Horimai Chihiro, Hayashi Matsuhiko

Abstract excerpt

BACKGROUND: Krüppel-like factor 4 (Klf4) is involved in a variety of cellular functions by activating or repressing the transcription of multiple genes. Results of previous studies showed that tamoxifen-inducible global deletion of the Klf4 gene in mice accelerated neointimal formation following vascular injury, in part via enhanced proliferation of smooth muscle cells (SMCs). Because Klf4 is also expressed in...

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Identifiers

PMID: 24470523
DOI: 10.1161/JAHA.113.000622
PMCID: PMC3959705

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