Beyond housekeeping: snRNA diversity, regulation, and human disease.

Abstract excerpt

Recent analyses challenge the long-standing view of small nuclear RNAs (snRNAs) as largely uniform and functionally interchangeable molecules. Their genes undergo lineage-specific expansions and losses, and in humans, individual loci display striking sequence constraints. Recurrent germline and somatic mutations cluster within defined structural domains of both major and minor spliceosomal snRNAs, revealing that...

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