Article

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

2022-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Chromosome 8 (chr8) gains are common in cancer. However, their potential contribution to tumor heterogeneity is largely unexplored. Ewing sarcoma (EwS) is characterized by pathognomonic FET::ETS fusions but a general paucity of other recurrent somatic mutations that could explain the observed clinical diversity. In EwS, chr8 gains are the second most common genetic alteration rendering EwS an i...

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Literature Corpus work: 49f95f43-8e11-5d90-8042-486bb7e7d9f0
DOI: 10.1101/2022.12.11.519935

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