Article
Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance.
JCO precision oncology - 1 Aug 2022
Ogura Koichi, Elkrief Arielle, Bowman Anita S, Koche Richard P, de Stanchina Elisa, Benayed Ryma, Mauguen Audrey, Mattar Marissa S, Khodos Inna, Meyers Paul A, Healey John H, Tap William D, Hameed Meera, Zehir Ahmet, Shukla Neerav, Sawyers Charles, Bose Rohit, Slotkin Emily, Ladanyi Marc
Abstract excerpt
PURPOSE: Ewing sarcoma (ES) is a primitive sarcoma defined by EWSR1-ETS fusions as the primary driver alteration. To better define the landscape of cooperating secondary genetic alterations in ES, we analyzed clinical genomic profiling data of 113 patients with ES, a cohort including more adult patients (> 18 years) and more patients with advanced stage at presentation than previous genomic cohorts. METHODS: The...
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