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Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma

2025-04-08

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms underlying tumor cell plasticity driving drug resistance and disease progression remain poorly understood. In Ewing sarcoma (EwS), variations in EWS::FLI1 (EF) activity have been associated with epithelial-mesenchymal plasticity (EMP). Using degron technology, we titrated endogenous EF in an EwS cell line and linked phenotypic states to distinct EF thresholds. Strikingly, modest E...

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Literature Corpus work
fb7fc8e7-c73e-530b-9d01-a185117d80b1
DOI
10.1101/2025.04.03.647002
Open publication

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