Article
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene - 8 Mar 2012
Mackintosh C, Ordóñez J L, García-Domínguez D J, Sevillano V, Llombart-Bosch A, Szuhai K, Scotlandi K, Alberghini M, Sciot R, Sinnaeve F, Hogendoorn P C W, Picci P, Knuutila S, Dirksen U, Debiec-Rychter M, Schaefer K-L, de Álava E
Abstract excerpt
Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite carrying a poor prognosis, are infrequent. In this scenario identifying secondary genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.