Article

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic Ewing sarcoma (EwS) remains a major clinical challenge, highlighting the need to identify molecular drivers of disease dissemination. Through integrated transcriptomic, functional, and mechanistic analyses, we identify PARP14 as a key regulator of EwS metastatic progression. PARP14 is consistently upregulated in metastatic lesions across spontaneous and xenograft mouse models as well...

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Literature Corpus work: 977500f7-bd46-5092-8294-2da865e140cf
DOI: 10.64898/2025.12.23.696151

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