cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EwS) is a highly aggressive pediatric malignancy driven by EWSR1::ETS fusion oncoproteins –primarily EWSR1::FLI1– which deregulate genes essential for differentiation, proliferation, and cell survival. To uncover key downstream targets of this fusion involved in cell differentiation, we combined transcriptomic profiling of EwS cell lines following EWSR1::FLI1 inhibition with gene...

Topics

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• Cancer Genomics and Diagnostics
• Cancer-related gene regulation
• Cell death mechanisms and regulation
• Lymphoma Diagnosis and Treatment
• Neuroblastoma Research and Treatments
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

d752d1fc-1045-5478-b53f-d6e2fe344c8e

DOI

10.1101/2025.06.27.661947