Article

Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma

2026-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic dissemination represents the major determinant of poor clinical outcome across cancer entities. Yet, how driver oncogenes shape transcriptional programs facilitating metastasis is poorly understood. In Ewing sarcoma (EwS) – a highly aggressive pediatric bone and soft-tissue sarcoma driven by chimeric FET::ETS transcription factors – low activity of the fusion oncoproteins is thought t...

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Literature Corpus work: 83738d4e-953c-5566-b4b9-aa5d48b69e43
DOI: 10.64898/2026.08.27.747513

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