Article

<i>Tex19.1</i> Restricts LINE-1 Mobilisation in Mouse Embryonic Stem Cells

2017-02-09

Abstract excerpt

Mobilisation of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution. In humans, retrotransposon mobilisation is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilise in pluripotent cells early in development. Here we show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the L1-en...

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Literature Corpus work: 49b1a303-167c-583f-96c0-c846cfca3b81
DOI: 10.1101/102442

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